Homogentisic Acid Oxidase*
نویسندگان
چکیده
In the course of a study of the properties of the homogentisic acid oxidase of rat liver the activity of other animal tissues has been briefly examined. The enzyme has been reported to occur in beef and hog (I), guinea pig (2), and rabbit (3) livers and in a strain of Pseudomonas (4). The experiments reported here show that the enzyme is also present in pigeon liver and in guinea pig, rabbit, pigeon, and rat kidney but absent in a variety of other tissues tested. Its presence in kidney prompted a reinvestigation of the ability of the rat kidney to oxidize L-tyrosine to acetoacetate.
منابع مشابه
The nature of the defect in tyrosine metabolism in alcaptonuria.
Alcaptonuria is a rare, hereditary, metabolic disorder characterized by a defect in the oxidation of tyrosine (l-3). In this condition homogentisic acid, an intermediary product of tyrosine degradation in mammalian liver, is excreted in the urine. This disorder has been attributed to an abnormality of the enzyme system, homogentisic acid oxidase, but the exact nature of the abnormality has not ...
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